Executive Summary
Chapter 1 A Foundation for Scientific Knowledge Management
Introduction
What is Knowledge Management?
KM Lessons Learned
Paper Laboratory Notebooks and ELN
The Use of ELN in a Knowledge Management Strategy
Chapter 2 Electronic Laboratory Notebooks
Definition of an ELN
Why an ELN?
ELN Evolution
ELN Architecture
ELN as a Component of Informatics Architecture
ELN Reference Architecture
Commercially Available ELN Products
DoitYourself Option
History of ELN
Chapter 2 Application of ELN to Example Use Cases
Synthetic Chemistry Single Product Reaction
Pharmacology Locomotor Study
Bioanalytical Procedure Execution ELN
Chapter 3 The Benefits of an ELN
Introduction
Example Case
User Experiences
General ELN Benefits
Downsides to an ELN Implementation
Chapter 4 Legal and Regulatory Considerations
Patents
Hybrid or Not?
Pharma and Electronic Records
Legal Changes Affecting Electronic Discovery
US Patent and Trademark Office
US Federal Rules of Evidence
Record Admissibility
Records Management
Record Preservation
Government Recognition of Electronic Records
Regulatory Considerations
Chapter 5 Technology
ELN in the Cloud
Survey of Potential ELN Users
Cloud Security
ELN Architectures
Web Services and Services Oriented Architectures
Data Types and Metadata
Information Lifecycle Management and Storage
Data Mining
Data Organization
Interoperability and Integration
Future Trends in ELN Technology
Accessing the ELN Software in the Laboratory
Chapter 6 Security, Integrity, Signatures, and Time Stamps
System Security
Introduction to the ISO 27001 series
Record Authentication and Digital Signatures
Digital Signatures, Public Key Cryptography
Time Authentication
Chapter 7 Change Management
Challenges
Data Management Challenges
Project Challenges
Frameworks for Change
Chapter 8 Defining a Project Strategy and Requirements
Strategic Implications of an ELN
Vision and Strategy Development Process through Product Selection
Building a Business Case - Calculating a Return on Investment
Chapter 9 Requirements
General Capabilities
Domain Specific Requirements
Chapter 10 Implementation
A Methodology for Implementation
Lessons Learned
Communication
Chapter 11 Market Drivers and Restraints
Biopharmaceuticals
Other Markets
Chapter 12 Size of the ELN Market
Background Data
R&D ELN Market Size - Units
R&D ELN Market Size – Software Sales
The Market for Systems in Quality Assurance and Control
Chapter 13 The Current Market for ELN
Sales made prior to 2011
R&D
Quality
Characteristics of ELN users
Supplier Market Positions
Dislikes
Changes in Support
Where systems are used
Comparison of Installed Domains to Areas of Potential Use
Perceptions of Suppliers
Chapter 14 ELN Products
Comparing Products
Accelrys – Symyx Notebook, iLabber (Contur)
Agilent Technologies – OpenLAB ELN
Arxspan – ArxLab
Asseco – shareSignELN
Axiope eCAT
Cognium Systems iPad
Edge Software Consultancy BioRails
iAdvantage eStudy
IDBS EWorkbook, BioBook, ChemBook
KineMatik eNovator
Laboratory Data Solutions Labnotes
LABTrack LABTrack ELN
LabWare – LabWare ELN
NoteBookMaker NoteBookMaker ELN
Microsoft Microsoft SharePoint
PerkinElmer Informatics ENotebook (Formerly CambridgeSoft), Nexxis (Formerly Labtronics)
Rescentris CERF
STARLIMS STARLIMS Electronic Notebook
VelQuest SmartLab
Waters Vision Publisher
Chapter 15 The Future of ELN
Appendix A
List of Figures and Tables
References
